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International guidelines for the use of the treatment lack clarity regarding the recommended type of corticosteroid and the gestational window of treatment administration.  A 2012 study from the U.K. compared the efficacy of corticosteroids and an oral antihistamine on preterm infants born prematurely, with preterm infants given aspirin and ibuprofen, before admission. The corticosteroids, cephalexin, propranolol, and prednisone reduced the proportion of infants born at less than 37 completed weeks of gestation by 50%, 45%, and 44%, respectively. The antihistamines, cimetidine and diphenhydramine, were neither indicated nor approved for the treatment of infants born preterm, but were used to reduce or prevent a reduction of the neonatal mortality rate (see the Cochrane Database of Systematic Reviews and Clinical Practice Guidelines (2014, 2013) for a discussion of the safety and efficacy of these drugs for the treatment of preterm infants.)  A 2014 study from the U.K., the U.S., Australia, Denmark, and France compared the effects of the different antihistamines, dexamethasone, dandruff, and chlorpheniramine, on pregnancy and neonatal outcomes in premature infants born at 26, 38, 40, and 45 weeks' gestation. Dexamethasone reduced the rate of preterm delivery, decreased the neonatal mortality rate, and increased the incidence of preterm delivery within 30 days of delivery. Dexamethasone increased the incidence of preterm delivery by 36%, decreased the rate of congenital anomalies by 48%, and increased the likelihood of still birth by 42%.  A 2013 study from the United Kingdom found an increased risk of congenital abnormalities (congenital heart defects and brain damage), intraventricular hemorrhage, and low birth weight when compared with placebo or corticosteroid.   In August, 2017, The Lancet published a large pooled analysis of observational studies that combined observational studies from across the world with randomized controlled trial data to address the question about the safety and efficacy of antihistamines in preterm infants born preterm.  The study found: In the pooled analysis by the researchers from Oxford University Health Alliance and Harvard Medical School, no effect was seen on preterm birth rates for any of the anti-histamines tested. However, the analysis did show a decrease in the rate of preterm birth with the use of diphenhydramine. While in early pregnancy, dexamethasone Similar articles: